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Παπανικολάου Ευάγγελος MD, MSc, PhD

Γυναικολόγος Εξωσωματικής Γονιμοποίησης και Υποβοηθούμενης Αναπαραγωγής στην Θεσσαλονίκη

Παπανικολάου Ευάγγελος Ιδρυτής Ιδρύματος
Ανθρώπινης Αναπαραγωγής και Γενετικής

Παπανικολάου Ευάγγελος γυναικολόγος

Το Ίδρυμα Ανθρώπινης Αναπαραγωγής και Γενετικής Η.R.G είναι ενεργό από το 2006.

Ο γιατρός γυναικολόγος εξωσωματικής γονιμοποίησης και υποβοηθούμενης αναπαραγωγής στην Θεσσαλονίκη κ. Παπανικολάου εκπαιδεύτηκε για 4 χρόνια, στο πιο πρωτοπόρο ίσως κέντρο εξωσωματκής στο κόσμο, στο Φλαμανδόφωνο Πανεπιστήμιο Βρυξελλών-Κέντρο Αναπαραγωγικής Ιατρικής, (Centrum voor Reproductieve Geneeskunde, Vrije Universiteit Brussel).

Η υπογονιμότητα είναι μία οργανική διαταραχή που δημιουργεί την αίσθηση του ασθενούς χωρίς όμως το σώμα να παρουσιάζει συμπτώματα ασθένειας στη πλειονότητα των περιπτώσεων.

Η ψυχολογική επιβάρυνση είναι τέτοια που έχει επιπτώσεις τόσο στη συμπεριφορά μας σαν άτομα όσο και στη σχέση με τον/την σύντροφό μας.

Στο Η.R.G θα συνειδητοποιήσετε ότι η υπογονιμότητα δεν σημαίνει στειρότητα και αργά ή γρήγορα θα αποκτήσετε παιδί, εφόσον διαπιστώσετε ότι είστε στο κατάλληλο ιατρικό περιβάλλον.

Η διερεύνηση της αιτιολογίας και η λογική χρήση εξετάσεων και διαγνωστικών επεμβάσεων (υστεροσκόπηση, λαπαροσκόπηση) θα οδηγήσει στην κατάλληλη θεραπεία, με γνώμονα την μεγιστοποίηση της πιθανότητας επίτευξης κύησης παράλληλα με το minimum κόστος.

Θα πρέπει να γίνει συνείδηση στα ζευγάρια ότι η Εξωσωματική Γονιμοποίηση δεν είναι πανάκεια και υπάρχουν απλούστερες μέθοδοι που προηγούνται στην αντιμετώπιση της υπογονιμότητας, εφόσον φυσικά έχουν ένδειξη.

Η συμμετοχή μας σε πολυκεντρικές μελέτες, όλα αυτά τα χρόνια, έχει σαν αποτέλεσμα να θέσουμε στην διάθεσή σας κάθε νέο φαρμακευτικό πρωτόκολλο και κάθε νέα εργαστηριακή μέθοδο που έχει γίνει standardized procedure.

Η Γενετική διερεύνηση σπανίων κληρονομικών ασθενειών είναι εφικτή και με την εφαρμογή της εξωσωματικής γονιμοποίησης μπορεί να αποφευχθεί η μετάδοσή τους στους απογόνους μας.

Ακρωνύμια όπως ICSI, TESE, MESA, FNA, και από την γενετική πλευρά PGD, PGS, HLA αποτελούν τεχνικές που βοηθούν αποφασιστικά τη σύλληψη σε ζευγάρια που τα προηγούμενα χρόνια θα έμεναν άτεκνα.

Τεχνικές όπως η καλλιέργεια βλαστοκύστεων, κατάψυξη εμβρύων, vitrification εμβρύων, προεμφυτευτικός γενετικός έλεγχος, δωρεά ωαρίων, δωρεά σπέρματος, βιοψία όρχεως και κατάψυξη ωαρίων αποτελούν καθημερινά όπλα στη φαρέτρα μας για την αντιμετώπιση extreme παθολογικών καταστάσεων.

Στο Ιδρυμα Ανθρώπινης Αναπαραγωγής και Γενετικής θα αισθανθείτε με την κατάλληλη ψυχολογική υποστήριξη ότι η ασφάλεια της γυναίκας προέχει και η γέννηση ενός υγιούς μωρού ακολουθεί.

Έτσι η υποβοηθούμενη αναπαραγωγή αποτελεί μια ευχάριστη εμπειρία και μία ακόμα κερδισμένη μάχη στον αγώνα της ζωής.

ΔΗΜΟΣΙΕΥΣΕΙΣ:

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2012

2011

Humaidan P, Papanikolaou EG, Kyrou D, Alsbjerg B, Polyzos NP, Devroey P, Fatemi HM. The luteal phase after GnRH-agonist triggering of ovulation: present and future perspectives. Reprod Biomed Online. 2011 Nov 9.

Papanikolaou EG, Humaidan P, Polyzos N, Kalantaridou S, Kol S, Benadiva C, Tournaye H, Tarlatzis B. New algorithm for OHSS prevention. Reprod Biol Endocrinol. 2011 Nov 3;9:147.

Humaidan P, Kol S, Papanikolaou EG; Copenhagen GnRH Agonist Triggering Workshop Group. GnRH agonist for triggering of final oocyte maturation: time for a change of practice? Hum Reprod Update. 2011 Jul-Aug;17(4):510-24. Epub 2011 Mar 30. Review.

Polyzos NP, Fatemi HM, Zavos A, Grimbizis G, Kyrou D, Velasco JG, Devroey P, Tarlatzis B, Papanikolaou EG. Aromatase inhibitors in post-menopausal endometriosis. Reprod Biol Endocrinol. 2011 Jun 21;9:90. Review.

Papanikolaou EG, Polyzos NP, Humaidan P, Pados G, Bosch E, Tournaye H, Tarlatzis B. Aromatase inhibitors in stimulated IVF cycles. Reprod Biol Endocrinol. 2011 Jun 21;9:85. Review.

Polyzos NP, Valachis A, Patavoukas E, Papanikolaou EG, Messinis IE, Tarlatzis BC, Devroey P. Publication bias in reproductive medicine: from the European Society of Human Reproduction and Embryology annual meeting to publication. Hum Reprod. 2011 Jun;26(6):1371-6. Epub 2011 Feb 28.

Kyrou D, Fatemi HM, Zepiridis L, Riva A, Papanikolaou EG, Tarlatzis BC, Devroey P.Does cessation of progesterone supplementation during early pregnancy in patients treated with recFSH/GnRH antagonist affect ongoing pregnancy rates? A randomized controlled trial. Hum Reprod. 2011 May;26(5):1020-4.

Papanikolaou EG, Verpoest W, Fatemi H, Tarlatzis B, Devroey P, Tournaye H. A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study. Fertil Steril. 2011 Mar 1;95(3):1174-7. Epub 2010 Oct 27.

Kolibianakis EM, Venetis CA, Kalogeropoulou L, Papanikolaou E, Tarlatzis BC. Fixed versus flexible gonadotropin-releasing hormone antagonist administration in in vitro fertilization: a randomized controlled trial. Fertil Steril. 2011 Feb;95(2):558-62.

2010

Polyzos NP, Polyzos IP, Zavos A, Valachis A, Mauri D, Papanikolaou EG, Tzioras S, Weber D, Messinis IE. Obstetric outcomes after treatment of periodontal disease during pregnancy: systematic review and meta-analysis. BMJ. 2010 Dec 29;341:c7017.

Papanikolaou EG, Fatemi H, Camus M, Kyrou D, Polyzos NP, Humaidan P, Tarlatzis B, Devroey P, Tournaye H. Higher birth rate after recombinant hCG triggering compared with urinary-derived hCG in single-blastocyst IVF antagonist cycles: a randomized controlled trial. Fertil Steril. 2010 Dec;94(7):2902-4.

Donoso P, Staessen C, Collins J, Verpoest W, Fatemi HM, Papanikolaou EG, Devroey P. Prognostic factors for delivery in patients undergoing repeated preimplantation genetic aneuploidy screening. Fertil Steril. 2010 Nov;94(6):2362-4.

Polyzos NP, Messini CI, Papanikolaou EG, Mauri D, Tzioras S, Badawy A, Messinis IE. Vaginal progesterone gel for luteal phase support in IVF/ICSI cycles: a meta-analysis. Fertil Steril. 2010 Nov;94(6):2083-7. Epub 2010 Feb 19.

Papanikolaou EG, Humaidan P, Polyzos NP, Tarlatzis B. Identification of the high-risk patient for ovarian hyperstimulation syndrome. Semin Reprod Med. 2010 Nov;28(6):458-62. Epub 2010 Nov 16. Review.

Humaidan P, Quartarolo J, Papanikolaou EG. Preventing ovarian hyperstimulation syndrome: guidance for the clinician. Fertil Steril. 2010 Jul;94(2):389-400.

Papanikolaou EG, Bourgain C, Fatemi H, Verpoest W, Polyzos NP, De Brabanter A, Kolibianakis E, Tarlatzis B, Devroey P, Tournaye H. Endometrial advancement after triggering with recombinant or urinary HCG: a randomized controlled pilot study. Reprod Biomed Online. 2010 Jul;21(1):50-5. Epub 2010 Mar 28.

Humaidan P, Papanikolaou EG, Tarlatzis BC. Reply: GnRHa to trigger final oocyte maturation: a time to reconsider. Hum Reprod. 2010 Mar;25(3):807-8.

Papanikolaou EG, Fatemi H, Venetis C, Donoso P, Kolibianakis E, Tournaye H, Tarlatzis B, Devroey P. Monozygotic twinning is not increased after single blastocyst transfer compared with single cleavage-stage embryo transfer. Fertil Steril. 2010 Feb;93(2):592-7.

2009

2008

Papanikolaou EG, Kolibianakis EM, Pozzobon C, Tank P, Tournaye H, Bourgain C, Van Steirteghem A, Devroey P. Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer. Fertil Steril. 2009 Mar;91(3):949-52. PubMed PMID: 17555751.

Verpoest W, Fauser BC, Papanikolaou EG, Staessen C, Van Landuyt L, Donoso P, Tournaye H, Liebaers I, Devroey P. Chromosomal aneuploidy in embryos conceived with unstimulated cycle IVF. Hum Reprod. 2008 Oct;23(10):2369-71. PubMed PMID: 18621755.

Fatemi HM, Popovic-Todorovic B, Donoso P, Papanikolaou EG, Smitz J, Devroey P. Luteal phase oestradiol suppression by letrozole: a pilot study in oocyte donors. Reprod Biomed Online. 2008 Sep;17(3):307-11. PubMed PMID: 18764999.

Loutradi KE, Kolibianakis EM, Venetis CA, Papanikolaou EG, Pados G, Bontis I, Tarlatzis BC. Cryopreservation of human embryos by vitrification or slow freezing: a systematic review and meta-analysis. Fertil Steril. 2008 Jul;90(1):186-93. Review. PubMed PMID: 17980870.

Verpoest W, De Rademaeker M, Sermon K, De Rycke M, Seneca S, Papanikolaou EG, Spits C, Van Landuyt L, Van der Elst J, Haentjens P, Devroey P, Liebaers I. Real and expected delivery rates of patients with myotonic dystrophy undergoing intracytoplasmic sperm injection and preimplantation genetic diagnosis. Hum Reprod. 2008 Jul;23(7):1654-60. PubMed PMID: 18408243.

Kolibianakis EM, Venetis CA, Papanikolaou EG, Diedrich K, Tarlatzis BC, Griesinger G.Estrogen addition to progesterone for luteal phase support in cycles stimulated with GnRH analogues and gonadotrophins for IVF: a systematic review and meta-analysis. Hum Reprod. 2008 Jun;23(6):1346-54. Review. PubMed PMID: 18408017.

Lainas TG, Sfontouris IA, Papanikolaou EG, Zorzovilis JZ, Petsas GK, Lainas GT, Kolibianakis EM. Flexible GnRH antagonist versus flare-up GnRH agonist protocol in poor responders treated by IVF: a randomized controlled trial. Hum Reprod. 2008 Jun;23(6):1355-8. PubMed PMID: 18403419.

Papanikolaou EG, Kolibianakis EM, Tournaye H, Venetis CA, Fatemi H, Tarlatzis B, Devroey P. Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis. Hum Reprod. 2008 Jan;23(1):91-9.Review. PubMed PMID: 17965420.

2007

Kolibianakis EM, Papanikolaou EG, Tournaye H, Camus M, Van Steirteghem AC, Devroey P. Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone. Fertil Steril. 2007 Nov;88(5):1382-8. PubMed PMID: 17445806.

Fatemi HM, Popovic-Todorovic B, Papanikolaou EG, Donoso P, Devroey P. An update of luteal phase support in stimulated IVF cycles. Hum Reprod Update. 2007 Nov-Dec;13(6):581-90 Review. PubMed PMID: 17626114.

Griesinger G, Kolibianakis EM, Papanikolaou EG, Diedrich K, Van Steirteghem A, Devroey P, Ejdrup Bredkjaer H, Humaidan P. Triggering of final oocyte maturation with gonadotropin-releasing hormone agonist or human chorionic gonadotropin. Live birth after frozen-thawed embryo replacement cycles. Fertil Steril. 2007 Sep;88(3):616-21. PubMed PMID: 17451691.

Kolibianakis EM, Kalogeropoulou L, Griesinger G, Papanikolaou EG, Papadimas J, Bontis J, Tarlatzis BC. Among patients treated with FSH and GnRH analogues for in vitro fertilization, is the addition of recombinant LH associated with the probability of live birth? A systematic review and meta-analysis. Hum Reprod Update. 2007 Sep-Oct;13(5):445-52. PubMed PMID:17586849.

Venetis CA, Kolibianakis EM, Papanikolaou EG, Bontis J, Devroey P, Tarlatzis BC. Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis. Hum Reprod Update. 2007 Jul-Aug;13(4):343-55. PubMed PMID: 17405832.

Tarlatzis BC, Papanikolaou EG. Multifollicular ovarian stimulation for IVF: more may not be better. Gynecol Endocrinol. 2007 Jun;23(6):307-8. PubMed PMID: 17616852.

Fatemi HM, Bourgain C, Donoso P, Blockeel C, Papanikolaou EG, Popovic-Todorovic B, Devroey P. Effect of oral administration of dydrogestrone versus vaginal administration of natural micronized progesterone on the secretory transformation of endometrium and luteal endocrine profile in patients with premature ovarian failure: a proof of concept. Hum Reprod. 2007 May;22(5):1260-3. PubMed PMID: 17227809.

Donoso P, Verpoest W, Papanikolaou EG, Liebaers I, Fatemi HM, Sermon K, Staessen C, Van der Elst J, Devroey P. Single embryo transfer in preimplantation genetic diagnosis cycles for women <36 years does not reduce delivery rate. Hum Reprod. 2007 Apr;22(4):1021-5. PubMed PMID: 17204531.

Fatemi HM, Camus M, Kolibianakis EM, Tournaye H, Papanikolaou EG, Donoso P, Devroey P. The luteal phase of recombinant follicle-stimulating hormone-gonadotropin-releasing hormone antagonist in vitro fertilization cycles during supplementation with progesterone or progesterone and estradiol. Fertil Steril. 2007 Mar;87(3):504-8. PubMed PMID: 17140572.

Della Ragione T, Verheyen G, Papanikolaou EG, Van Landuyt L, Devroey P, Van Steirteghem A. Developmental stage on day-5 and fragmentation rate on day-3 can influence the implantation potential of top-quality blastocysts in IVF cycles with single embryo transfer. Reprod Biol Endocrinol. 2007 Jan 26;5:2. PubMed PMID: 17257401; PubMed Central PMCID: PMC1796880.

2006

Fatemi HM, Kolibianakis, EM, Camus, M, Tournaye, H, Donoso, P, Papanikolaou EG, and Devroey, 21 P (2006) Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial. Hum,Reprod,2628-32.

Donoso P, Platteau, P, Papanikolaou EG, Staessen, C, Van Steirteghem, A and Devroey, P (2006) Does PGD for aneuploidy screening change the selection of embryos derived from testicular sperm extraction in obstructive and non-obstructive azoospermic men? Hum Reprod , 21, 2390-5.

Verpoest WM, Kolibianakis, E, Papanikolaou EG, Smitz, J, Van Steirteghem, A and Devroey, P (2006) Aromatase inhibitors in ovarian stimulation for IVF/ICSI: a pilot study. Reprod Biomed Online, 13, 166-72.

Kolibianakis EM, Papanikolaou EG, Camus, M, Tournaye, H, Van Steirteghem, AC and Devroey, P (2006) Menstruation-free interval and ongoing pregnancy in IVF using GnRH antagonists. Hum Reprod, 21, 1012-7.

Papanikolaou EG, Camus, M, Kolibianakis, EM, Van Landuyt, L, Van Steirteghem, A and Devroey, P (2006) In vitro fertilization with single blastocyst-stage versus single cleavage-stage embryos. N Engl J Med, 354, 1139-46.

Kolibianakis EM, Papanikolaou EG, Camus, M, Tournaye, H, Van Steirteghem, AC and Devroey, P (2006) Effect of oral contraceptive pill pretreatment on ongoing pregnancy rates in patients stimulated with GnRH antagonists and recombinant FSH for IVF. A randomized controlled trial. Hum Reprod, 21, 352-7.

Kolibianakis EM, Collins, J, Tarlatzis, B, Papanikolaou EG, and Devroey, P (2006) Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review. Hum Reprod Update, 12, 3-12.

Papanikolaou EG, Pozzobon, C, Kolibianakis, EM, Camus, M, Tournaye, H, Fatemi, HM, Van Steirteghem, A and Devroey, P (2006) Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles. Fertil Steril, 85, 112-20.

Papanikolaou EG, Camus, M, Fatemi, HM, Tournaye, H, Verheyen, G, Van Steirteghem, A and Devroey, P (2006) Early pregnancy loss is significantly higher after day 3 single embryo transfer than after day 5 single blastocyst transfer in GnRH antagonist stimulated IVF cycles. Reprod Biomed Online, 12, 60-5.

2005

Papanikolaou EG, D’haeseleer, E, Verheyen, G, Van de Velde, H, Camus, M, Van Steirteghem, A, Devroey, P and Tournaye, H (2005) Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. A randomized prospective study. Hum Reprod, 20, 3198-203.

Papanikolaou EG, Vernaeve, V, Kolibianakis, E, Assche, EV, Bonduelle, M, Liebaers, I, Van Steirteghem, A and Devroey, P (2005) Is chromosome analysis mandatory in the initial investigation of normovulatory women seeking infertility treatment? Hum Reprod, 20, 2899-903.

Fatemi HM, Al-Turki, HA, Papanikolaou EG, Kosmas, L, De Sutter, P and Devroey, P (2005) Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor. Reprod Biomed Online, 11, 455-7.

Kolibianakis EM, Bourgain, C, Papanikolaou EG, Camus, M, Tournaye, H, Van Steirteghem, AC and Devroey, P (2005) Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles. Hum Reprod, 20, 2453-6.

Papanikolaou EG, Bourgain, C, Kolibianakis, E, Tournaye, H and Devroey, P (2005) Steroid receptor expression in late follicular phase endometrium in GnRH antagonist IVF cycles is already altered, indicating initiation of early luteal phase transformation in the absence of secretory changes. Hum Reprod, 20, 1541-7.

Kolibianakis EM, Papanikolaou EG, Fatemi, HM and Devroey, P (2005) Estrogen and folliculogenesis: is one necessary for the other? Curr Opin Obstet Gynecol, 17, 249-53.

Papanikolaou EG, Platteau, P, Albano, C, Nogueira, D, Cortvrindt, R, Devroey, P and Smitz, J (2005) Immature oocyte in-vitro maturation: clinical aspects. Reprod Biomed Online, 10, 587-92.

Papanikolaou EG, Kolibianakis, E and Devroey, P (2005) Emerging drugs in assisted reproduction. Expert Opin Emerg Drugs, 10, 425-40.

Papanikolaou EG, Tournaye, H, Verpoest, W, Camus, M, Vernaeve, V, Van Steirteghem, A and Devroey, P (2005) Early and late ovarian hyperstimulation syndrome: early pregnancy outcome and profile. Hum Reprod, 20, 636-41.

Papanikolaou EG, Platteau, P, Albano, C, Kolibianakis, E and Devroey, P (2005) Achievement of pregnancy three times in the same patient during luteal GnRH agonist administration. Reprod Biomed Online, 10, 347-9.

2004

2003

2002

Ερευνητικά Προγράμματα (Gene expression στο Ενδομήτριο)

Ερευνητικά Προγράμματα (Agonist Triggering για την αποφυγή συνδρόμου υπερδιέγερσης OHSS)

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